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2016-09-17 17:00 网络整理 教案网

"... To clarify the involvement of prefrontal cortex in episodic memory, behavioral and event-related potential (ERP) measures of recognition were examined in patients with dorsolateral prefrontal lesions. In controls, recognition accuracy and the ERP old-new effect declined with increasing retention int ..."

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To clarify the involvement of prefrontal cortex in episodic memory, behavioral and event-related potential (ERP) measures of recognition were examined in patients with dorsolateral prefrontal lesions. In controls, recognition accuracy and the ERP old-new effect declined with increasing retention intervals. Although frontal patients showed a higher false-alarm rate to new words, their hit rate to old words and ERP old-new effect were intact, suggesting that recognition processes were not fundamentally altered by prefrontal damage. The opposite behavioral pattern was observed in patients with hippocampal lesions: a normal false-alarm rate and a precipitous decline in hit rate at long lags. The intact ERP effect and the change in response bias during recognition suggest that frontal patients exhibited a deficit in strategic processing or postretrieval monitoring, in contrast to the more purely mnemonic deficit shown by hippocampal patients. Human memory is not a monolithic phenomenon but rather is composed of different subsystems that are implemented by separate brain regions. Explicit or declarative memory, the ability to recall some event or recognize a particular stimulus, is dependent on medial temporal lobe (MTL), diencephalic, and basal forebrain structures (Zola-Morgan & Squire, 1993). An important (although disputed) subdivision of memory is the distinction between episodic memory for personally experienced events and semantic memory for facts and general world knowledge (Tulving, 1983). Neuropsychological studies have established the importance of the frontal lobes in specific types and aspects

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