吉林省长春市健身教练培训难不难赛普力量教育基地(6)
2019-12-13 22:03
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csofecbinrats.thepharmacokineticparametersofecb一glueuronidewereestimatedinratsfollowingasingle一doseoraladministrationof100mg/kg.inrats，ecbwasrapidlymetabolizedtoitsmonoglueuronideandtheglueuronidewastheonlydrug一derivedeompoundelearlydeteetedinplasma.two一eompartmentmodelwasusedtoestimateecb一glueuronidepharlllaeokineticsbyusingdassoftware.theplasmaprofileofecb一glueuronidewasfoundtoberapidwithanapparenttmaxoeeurringat4h，indieatingthatecbwasrapidlyabsorbedinratsfollowinganoraladministration.inratsfollowinganoraladministrationofnca，nometaboliteswereevidentlydetectedinplasma.moreover，theparentdrugncawasobservedinplasmaonlyintraceamounts，indieatingthattheoralabsorptionofncainvivomaybepoor.onereasonleadingtothepoororalabsorptionofncawasprobablytheinvolvementofp一gp.v11浙江大学博士学位论文英文摘要4.metabolismofecbandncastudiedinvitrowithhumanlivermierosomes，hepgzcellsandreeombinanthumanenzylllesthemetabolieprofileinhumanlivermicrosomeswaseonsistentwiththatobservedinratlivermierosomesandrats，indieatingglueuronidationwasprobablythemajormetaboliepathwayofecbinhumans.wllenncawasineubatedwithhumanlivermicrosomes，onlyonemonoglucuronidewasobserved.theeatalytieisoen-zylllesprobablyinvolvedinecbandncametabolisminhumanswereidentifiedbyusingseleetiveehemiealinhibitioninhumanlivermierosomesandreeoxnbinanthumanenlzyllles.theresultsindieatedcyp3a4，ugtia6/9，espeeiallycyp3a4andugtia6，wereimportanteatalytieen-zylnesinecbmetabolism.ugtia3/6/9wereimportantcatalyticenzymesinncaglucuronidationmetabolism.nometabolitesweredeteetedafterncawasineubatedwithhepgzcells:noglucuronideandonlytraeemonoh州roxylationmetabolitewereobservedafterecbwasineubatedwithhepgzeells，indicatingthemetabolicabilitytowardecbandnca15verylow.keywords:ebraeteolataeompoundb:neochamaejasmina:recombinanthumanenzyllles
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